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iwAL 2022 Session V: mechanisms of resistance to targeted therapies in AML

VJHemOnc Podcast

CHAPTER

Mechanisms of Resistance in IDH and Flit3 Mutant AML

This chapter explores the resistance mechanisms to targeted therapies in IDH and Flit3 mutant AML, discussing the impact of small clones, non-cell intrinsic effects, and the role of 2Hg. It also highlights the low response rates in treating relapse wild type Flit3 and the need for further understanding.

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