The Pharmacology of Cytarabine

This chapter explores the history and development of cyterabine from its discovery in a Caribbean sea sponge to its pharmacological applications in treating acute myeloid leukemia. It discusses critical factors such as dosing strategies, metabolism, and the challenges associated with administering the drug to patients with renal dysfunction. Emphasizing the importance of pharmacokinetics, the chapter addresses the complexities and risks involved in high-dose therapy while navigating treatment adjustments based on individual patient factors.