This chapter explores the main contributing factors to autoimmunity, including genetics, diet boundaries, intestinal permeability, and triggers like viruses, trauma, and emotional conflicts. It discusses the prevalence of autoimmunity globally, the impact of exposure to a diverse array of microbes on immune modulation, and the effects of decreased exposure to dirt and soil microbes in modern society. The conversation also delves into a functional medicine physician's personal experience with resolving trauma using MDMA-assisted therapy and the significant effectiveness of this approach in treating trauma and improving health markers.

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