A Zonal Oxlang for the Andes Mountains?

A zonal oxlang for all of North America would be almost impossible because there are such radically different language families. The problem is that you have things like Tagalog on the one hand, which still has the Austronesian alignment, and then way off at the other end, you get Hawaii,. So you'd get something that looked an awful lot like a Polynesian language I think. What would be interesting actually is an Austronesian zonal ox line.