Navigating Real-World Evidence and Methodology

This chapter emphasizes the critical role of precise research questions in real-world evidence and clinical trials, addressing how ambiguity can skew interpretations of treatment effectiveness. It explores the challenges of missing data, methodological choices, and the importance of transparency in fostering trust and innovation in drug development. Finally, it highlights the need for creative statistical approaches while balancing the intricacies of real-world data with rigorous scientific standards.