C-fiber tells your brain how you wake up. That's why it is difficult to sleep after nociceptive stimuli or through experiencing pain. The other thing is that these fibers speak to a deep part of the brain just below the thalamus, called the hypo thalamus. It plays an important role in an autonomic nervous system, particularly sympathetic. And then we know that's a fight and flight. So that will start to cause changes in bodily systems.