US doc's pay, the ticagrelor controversy and new RCTs, clopidogrel beats ASA, holding antiplatelets for non-cardiac surgery, and Prof Cleland and ASA dogma are the topics John Mandrola, MD, covers this week.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. US Healthcare
Mandrola’s Top 10 Stories in 2024 https://www.medscape.com/viewarticle/mandrolas-top-10-stories-2024-2024a1000mxe?_gl=1*dcvmkh*_gcl_au*MTgzOTY2ODQ0Ni4xNzI5MjU4NjUz
II. Ticagrelor Controversy
New Investigation Casts Doubt on Landmark Ticagrelor Trial
https://www.medscape.com/viewarticle/new-investigation-casts-doubt-landmark-ticagrelor-trial-2024a1000n1d
- Doshi Review https://www.bmj.com/content/387/bmj.q2550
- PLATO https://www.nejm.org/doi/full/10.1056/NEJMoa0904327
- ISAR REACT 5 https://www.nejm.org/doi/full/10.1056/NEJMoa1908973
- Bates Review https://www.ahajournals.org/doi/epub/10.1161/JAHA.123.031606
- Victor Serebuany and Dan Atar Editorial https://doi.org/10.1093/eurheartj/ehp545
III. New Ticagrelor vs Clopdiogrel trial
- Preprint: https://www.medrxiv.org/content/10.1101/2024.11.06.24316875v1.full-text
IV. Clopidogrel Better Than ASA Even in HBR
- Substudy Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity
- HOST-EXAM 10.1016/S0140-6736(21)01063-1
- HOST-EXAM-Extended https://doi.org/10.1161/CIRCULATIONAHA.122.062770
V. ASA During Non-Cardiac Surgery
- ASSURE DES https://doi.org/10.1016/j.jacc.2024.08.024
VII. Professor Cleland on ASA for Secondary Prevention
- Cleland Editorial https//jamanetwork.com/journals/jamacardiology/article-abstract/2827201
- ASA Meta-analysis 10.1016/S0140-6736(09)60503-1
- AMIS https://jamanetwork.com/journals/jama/fullarticle/368745
- SAPAT 10.1016/0140-6736(92)92619-Q
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