Oncotarget published this trending research perspective on June 22, 2021, entitled, "Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study" by researchers from Duke University, Durham, NC; University of Lagos, Lagos State, Nigeria; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria; University College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria; Federal Medical Center, Abeokuta, Ogun State, Nigeria; UNC Gillings School of Global Public Health, Chapel Hill, NC; Our Lady of Apostle Catholic Hospital, Ibadan, Oyo State, Nigeria; University of Alabama at Birmingham, AL; University of Kentucky, Lexington, KY; University of Kansas Medical Center, Kansas City, KS.
In this study, 555 Nigerian participants were assembled—of which 296 were confirmed breast cancer cases, and 259 were controls. The researchers collected clinical and reproductive characteristics of each participant, including the controls. In their first analysis, the researchers observed that newly diagnosed cases of Nigerian breast cancer were significantly more likely to have high levels of highly-sensitive CRP (hsCRP) compared to the controls. After adjusting for socio-demographic, clinical, and reproductive variables, the team still observed significant statistical significance for high levels of hsCRP associated with Nigerian BC. The findings from this cohort study also showed that high hsCRP was associated with a four-fold increased odds of BC.
“We also provide novel evidence of associations between hsCRP and BC molecular subtypes, with significant associations observed for luminal A, TN, and HER-enriched subtypes.”
Full blog - https://www.oncotarget.org/2021/08/12/trending-with-impact-analysis-of-breast-cancer-in-nigerian-women/
Press release - https://www.oncotarget.com/news/pr/oncotarget-odds-of-breast-cancer-by-molecular-subtype-analysis-of-the-mend-study/
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DOI - https://doi.org/10.18632/oncotarget.27991
Full text - https://www.oncotarget.com/article/27991/text/
Correspondence to - Tomi Akinyemiju - tomi.akinyemiju@duke.edu
Keywords - C-reactive protein, breast cancer, Nigeria, molecular subtype, menopausal status
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