

Pleiotropy, Natural Selection, and the Evolution of Senescence
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Book •
This influential paper by George C. Williams explores the concept of antagonistic pleiotropy as an explanation for the evolution of senescence.
It builds upon ideas similar to those of Peter Medawar, discussing how natural selection's effectiveness decreases with age, leading to the accumulation of genes with early benefits but late-life costs.
It builds upon ideas similar to those of Peter Medawar, discussing how natural selection's effectiveness decreases with age, leading to the accumulation of genes with early benefits but late-life costs.