Most people are familiar with DNA, but its cousin, RNA, has become widely known only recently. In 2020, of course, RNA was in the news all the time: the COVID-19 virus is made of RNA, as are the vaccines to combat it. Technologies based on RNA could lead to innovations in biology, medicine, agriculture, and beyond, but researchers have only scratched the surface of understanding what RNA is capable of.

A new report from the National Academies, Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine, proposes an ambitious road map for coordinated projects to understand RNA. This large-scale effort is inspired by what was achieved for DNA two decades ago by the Human Genome Project.

On this episode, host Monya Baker is joined by Lydia Contreras, professor of chemical engineering at the University of Texas, Austin, and one of the authors of the report. Contreras talks about what RNA is, the challenges and potential of this effort, and what lessons could be learned from previous efforts with the Human Genome Project.

Resources:

Read the full National Academies report: Charting a Future for Sequencing RNA and Its Modifications: A New Era for Biology and Medicine.

Visit the Contreras Research Lab website to learn more about Lydia Contreras’s work.

Retrospectives on the Human Genome Project.

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